Abstract: The Hongling lead-zinc deposit in the southern Great Xing'an Range serves as a typical example of multistage tectono-magmatic-hydrothermal superimposed mineralization. Its complex genesis is of significant importance for deepening the understanding of regional metallogeny and guiding prospecting and exploration. Based on systematic field geological investigations and petrographic as well as ore microscopic observations, combined with analysis of mineral paragenesis, textures and structures, and fluid evolution characteristics, this study identifies two main mineralization episodes in the Hongling deposit, which are further subdivided into six metallogenic stages. The results indicate that the first mineralization episode, associated with the emplacement of Early Cretaceous granite, underwent a complete hydrothermal evolution sequence typical of skarn-type deposits, progressing through the skarn stage, oxide stage, sulfide stage, and the carbonate stage. The second mineralization episode is manifested by garnet-magnetite veins and Pb-Zn-carbonate veins that cut through and overprint the earlier ore bodies, revealing at least two relatively independent yet genetically linked hydrothermal systems. The multistage superimposed mineralization characteristics of the Hongling deposit suggest the potential existence of mineralization centers from different stages at depth. Prospecting efforts should therefore focus on zones where mineralizations from different episodes overlap, particularly the intersection zones between early skarn-magnetite orebodies and later sulfide veins. Concurrently, careful discrimination of the alteration features associated with hydrothermal activities of different episodes is essential. This study provides important constraints for refining the regional metallogenic series in the southern Great Xing'an Range, enhancing the genetic understanding of skarn-type deposits, and guiding deep and peripheral exploration.