Mine ventilation system serves mining production.Independent and stable operation of ventilation system plays an important role in mine safety production.In light of the technical challenges of mine ventilation in Yangzhaiyu Mine of Qinling Mining Co.,Ltd.，such as many intersecting points of adjacent mines,scattered space of residual mining sites and  incomplete return air system,a 3D model of mine ventilation system is established by Ventsim ventilation simulation software through field investigation of regional environment and mines.For energy-saving and efficient independent ventilation system by isolating adjacent mining sites,the study proposed the optimization plan of a single wing diagonal air return series-parallel fan station ventilation system.Through the analysis and evaluation of the main fan status and air speed at main fan spots,it is concluded that the new ventilation system meets the production requirements of the mine at present stage,and has remarkable onsite application value.