The flotation operation of the ore-dressing system in a gold mine is challenged by poor slurry enrichment,thin foams layers,and vulnerable foams that dont perform in carrying concentrates.The flotation index is negatively affected.To improve the flotation index and mitigate metal loss,the experimental study to optimize the flotation reagent regime as well as its production practice is carried out.The results show that the new type of collector has a good flotation effect on the ore and is highly selective;the new reagent regime is established by sodium carbonate,copper sulfate,and the new collector.By optimizing the new regime,the enrichment of the slurry becomes better,the foam layer becomes thicker and the concentrate carrying effect is better,significantly improving the flotation index.While the concentrate productivity is slightly lower,the gold grade of the concentrates increases by 1.69 g/t,the gold recovery rate increases by 1.79 percentage points,the gold grade of tailings decreases by 0.12 g/t,and the economic profits are increased.