In order to improve the deep ventilation conditions at Fankou Lead-Zinc Mine,the air volume and resistance were measured and the air volume demand was calculated.The total air inlet and return of the deep ventilation system were 330.38 m3/s and 345.95 m3/s,respectively.The total air resistance in the deep panel is 0.012 3 N·s2/m8.In order to solve the problems of unreasonable distribution of air volume,lengthy ventilation lines,and high resistance among deep levels and working faces,4 optimization schemes are proposed and simulated in 3D.The results show that the optimization and transformation of the deep ventilation system should choose the scheme of adding air inlet and return shafts & setting multi-stage ventilators,which can not only realize on-demand air flow in different levels and stopes.It can also increase the air volume that enters each level and sublevel stope to meet future production needs.