This study investigates the effects of different types of collectors on the flotation separation of copper,lead,and  zinc  in a polymetallic mine in Qinghai.The emphasis was placed on evaluating the separation efficiency of new types of collectors 4037B,P5100C,and QBSC.The results indicate that P5100C and QBSC are particularly effective for the separation of copper and lead.Under optimal conditions,a process comprising rapid flotation of copper-mixed flotation of copper and lead-regrinding and separation of copper and lead-zinc flotation,yielded a copper concentrate with a grade of 35.56 % and a recovery rate of 75.23 %,a lead concentrate with a grade of 45.02 % and a recovery rate of 71.92 %,and a zinc concentrate with a grade of 41.49 % and a recovery rate of 72.58 %.A mixed concentrate was also obtained with copper grades of 20.14 %,lead grades of 8.90 %,zinc grades of 28.38 %,and recovery rates of 11.93 %,6.77 %,and 11.81 % for copper,lead,and zinc,respectively.The overall copper,lead,and zinc recovery rates were 97.94 %,96.62 %,and 92.64 %,respectively.