The selection of an appropriate mining method is critical to the survival and development of mining enterprises, directly impacting safety, production efficiency, and economic benefits. This is particularly important for mines with complex technical conditions for orebody extraction. Drawing on domestic and international experience and taking into account the mining conditions and current situation of the Taohuazui mining district, several technically feasible mining methods for thick and large orebodies are proposed: mechanized upward horizontal slicing and filling mining method for panels, in-vein ramp-along-strike upward slicing and filling mining method, strip and slicing along strike mining method and filling with cemented backfills, mechanized upward slicing and filling mining method with in-vein preliminary mining, and integrated mining method of staged open stoping with reserved  protective walls and upward slicing. Through engineering analogy, theoretical analysis, and technical and economic comparison, the optimal mining method was identified as the intergrated mining method of staged open stoping with reserved protective walls and upward slicing. Field tests and application results indicate that this method has favorable technical and economic metrics, is highly compatible with the orebody conditions, and is suitable for promotion and application in similar orebodies and mines, offering valuable references.