Experimental study is carried out on the lead and zinc separation process,reagent regime and silver recovery of a low grade lead,zinc and silver polymetallic ore and the preferential flotation process suitable for the ore is determined.The results show that the preferential closed-circuit flotation flowsheet can obtain relatively good index and the silver is mainly enriched in lead concentrates; in the lead concentrates,lead,zinc and silver grade is 45.52 %,2.26 % and 2 470 g/t respectively,and lead and silver recovery rate is 73.24 % and 58.16 % respectively; in the zinc concentrates,zinc,lead and silver grade is 32.64 %,0.50 % and 178 g/t respectively,and zinc and silver recovery is 65.86 % and 2.50 % respectively; in the sulfide concentrates,sulfur grade is 36.18 % and sulfur recovery rate is 43.25 %.The lead,zinc,silver and sulfur are effectively separated and recovered.The study can provide technical support for the recovery of the polymetallic ore.