The mining of steeply inclined orebodies in the Lizi Gold Mine faces challenges such as thin orebodythickness and complex geological conditions, and the existing mining methods and technologies are difficult to meet theincreasingly stringent production demands. In order to optimize the blasting parameters, improve the orebody fragmenta‑tion effect, and reduce the ore grade dilution rate, the blasting parameters for the steeply inclined thin ore vein in theLizi Gold Mine were optimized by combining numerical simulation and field tests. By using the blasting simulation testof the surrounding rock of the stope and the orebody rock, the relationship between the rock damage rate and the peakparticle vibration velocity under the condition of the field‑used explosives was deeply analyzed. Through the analysis ofdifferent borehole parameter combinations, the optimal scheme was determined as a borehole combination with a 0.3 mstandoff distance and a 0.5 m row spacing. The optimized blasting parameters effectively improved the shape of the goafin the stope, reduced overbreak and underbreak phenomena, and ensured efficient and safe mining operations.