After stope blasting using strip filling method, underground metal mines encounter a series of problemssuch as overbreak, underbreak, and roof collapse. To precisely control the blasting range and reduce mining loss anddilution indicators, it is necessary to optimize the blasting parameters. Based on the engineering blasting practice at theTaipingdong Gold Mine, a systematic analysis of the influencing mechanisms of different blasting parameters on blastingquality was conducted through a technical approach combining mechanical property assessment and dynamic failureprocess simulation of the rock mass. Furthermore, research on optimizing rock drilling and blasting parameters for stopewall expansion was carried out. According to the rock blastability classification criteria, the orebody generally had mediumand easy blastability. Through collaborative optimization research on hole bottom spacing and minimum resistance line,when blast holes with a 42 mm diameter achieved ideal rock mass fragmentation morphology, the minimum resistanceline was 0.97-1.26 m; the hole bottom spacing was 1.19-1.55 m, and the distance from the blast hole center to the freesurface was 0.76-0.99 m. Simplified calculation models with different combinations of hole bottom spacing and minimumresistance line were constructed using ANSYS/LS-DYNA software, and numerical simulations of ore rock failurecharacteristics under explosive loading were performed. The following conclusions were drawn: When the minimumresistance line is greater than or equal to 1.0 m, the fragmentation quality of ore rock in some excavation areasdeteriorates, making it highly prone to generating large blocks. To balance the fragmentation effect and economic costs,the optimal hole network parameters are as follows: minimum resistance line of 1.0 m, hole bottom spacing of 1.23 m,and distance from blast hole center to free surface of 0.79 m.