Utilizing cyanide⁃containing tailings as filling aggregate for underground filling can effectively addressenvironmental issues caused by tailings pond storage, improve the utilization rate of solid waste resources, and reducefilling costs, demonstrating significant economic and environmental benefits. In this study, cyanide⁃containing tailingsslurry from a gold mine was treated using hydrogen peroxide oxidation and sodium percarbonate oxidation methods,with reagents and experimental conditions optimized. Results show that the easily released cyanide and main heavymetal contents in the toxic leachate of the treated tailings slurry are lower than the requirements for cyanide residuebackfilling specified in HJ 943-2018 technical specification for pollution control of cyanide leaching residue in goldindustry. After considering factors such as reagent cost, storage, transportation, and usage conditions, the sodium percar⁃bonate oxidation method is recommended. This study provides a reference for the detoxification treatment of cyanide⁃containing tailings as filling aggregate in the gold industry.