The incomplete sulfidation of Cu（Ⅰ）in cuprite leads to unsatisfactory recovery in sulfidation flotation.By using hydrogen peroxide as an oxidant, the effect of staged oxidation on the flotation behavior of cuprite throughstaged sulfidation was investigated. The interaction mechanism between reagents and mineral surface was revealedthrough Zeta potential measurements and X⁃ray photoelectron spectroscopy（XPS）analysis. Results demonstrate that in athree⁃stage oxidation and three⁃stage sulfidation flotation process, the highest total cuprite recovery of 95.85 % isachieved when the mass distribution ratio of reagents in each stage is 4∶1∶1. Further increasing the number of sulfidationflotation stages will reduce the overall recovery. XPS analysis shows that after three⁃stage oxidation and three⁃stagesulfidation treatment, more Cu（Ⅰ）on the cuprite surface is oxidized to Cu（Ⅱ）, gradually enhancing the surfacenegativity. The contents of S2− and SOn2− components continuously increase, while SOn2− content significantly decreasesand accounts for the smallest proportion in total sulfur components. These chemical changes on the surface facilitatethe formation of copper sulfide phases, creating more favorable conditions for collecting agent adsorption and consequentlyimproving the sulfidation flotation efficiency of cuprite.