Experimental research on the mixed flotation of a low-grade lead,zinc and gold polymetallic ore is carried out according to its ore property and investigates the effects of activator,regrinding fineness,cleaning regulator on the flotation index,in order to efficiently recover lead and zinc mineral resources.The results show that under optimal conditions,the mixed flotation closed circuit obtains good test index:the lead grade is 14.71 %,zinc grade is 31.54 %,gold grade is 22.30 g/t,lead recovery rate is 91.82 %,zinc recovery rate is 93.83 %,gold recovery rate is 75.62 % in the mixed concentrates.