The pre-treatment method of sodium peroxide base melting and the cationic exchange resin separation-inductively coupled plasma mass spectrometry were used to determine the elements of iodine,boron,germanium,tin,arsenic,phosphorus,molybdenum and tantalum.Various experimental parameters were examined and the optimum parameters were determined.The results show that the correlation coefficient of the standard curve of iodine,boron,germanium,tin,arsenic,phosphorus,molybdenum and tantalum was all ＞0.999 0,the detection limits were 0.2 μg/g,1 μg/g,0.06 μg/g,0.2 μg/g,0.2 μg/g,10 μg/g,0.1 μg/g,0.01 μg/g,respectively.The accuracy was below 0.1 and the precision was below 10 %,meeting the requirement of DZ/T 0258—2014 Specifications for Multi-purpose Regional Geochemical Survey(1∶250 000).