The lead and zinc grades of a polymetallic ore with high lead and low zinc content are 5.50 % and 0.37 % respectively.Galena,sphalerite,pyrite and chalcopyrite are closely related to metallic sulfide.It is difficult to separate lead and zinc.In light of these features,experimental research has been carried out on gravity separation-rapid flotation of gravity tailings-lead and zinc separation in flotation tailings.The results show that under optimal conditions,closed flotation circuit has obtained good index and effective separation of lead and zinc;in silver lead concentrates,overall lead recovery rate is 96.11 % and silver recovery rate is 92.36 %;in zinc concentrates,zinc grade is 52.45%,zinc recovery rate is 82.41 %;impurity content in each product meets the standards and the economic profits are significant.