A gold polymetallic ore from Kyrgyzstan is with variety of valuable elements and is characterized by complex occurrence status and fine disseminated particle size.According to the ore property,the effective preliminary separation of valuable metals in the gold polymetallic ore can be realized by adopting the process flow of copper flotation-gold cobalt mixed flotation.Closed circuit can obtain the copper concentrate containing 228.00 g/t Au with recovery of 12.19 %,974.00 g/t Ag with recovery of 37.71 %,27.590 % Cu with recovery of 80.65 %,and gold cobalt concentrate containing 65.00 g/t Au with recovery of 57.22 %,28.00 g/t Ag with recovery of 17.86 %,0.550 0 % Co with recovery of 53.02 %.