In order to effectively exploit low-grade refractory gold and silver resources,the paper takes the Au-Ag-Fe polymetallic oxide ores from Yunnan Province as the research subject and carries out pressurized cyanide leaching experimental study.The results show that under optimal test conditions and when Au grade,Ag grade and Cu grade of the primary ore are 1.57 g/t,37.20 g/t and 0.36 % respectively,the test can obtain good index:Au leaching rate 92.36 %,Ag leaching rate 47.31 % and Cu leaching rate 20.37 %;compared to atmospheric pressure in identical conditions,the pressurized cyanide leaching process is 2 percentage points higher as to gold leaching rate and 20 percentage points higher as to silver leaching rate,and can greatly shorten the leaching time.The research achievement can be used as reference to effectively exploit low-grade refractory gold and silver resources.