Proper mine ventilation system construction ensures safe and efficient underground operation.The study takes a mine in Guangxi as the research subject,simulates the mine ventilation system with Ventsim 3D software,calculates the overall air volume needed in the mine and measures the air volume in field.The study shows that Ventsim software can establish a reasonable mine ventilation system model.The inlet and outlet of air volume in the simulation are consistent with the infield measured volume.At the same time the simulation results also show that the air resistance is big,and the problem of air leakage and recycling in the system is severe.The study has guiding significance to the renovation of mine ventilation system.