The paper takes the ventilation system optimization project of Xitieshan Lead-Zinc Mine as the research subject,and optimizes the mine ventilation system.Based on field investigation,survey and analysis,3 ventilation system optimization plans are put forward.With comprehensive consideration of ventilation resistance,installation design cost and construction workload,the ventilation system optimization plan is decided to be the surface extraction type ventilation system plan where the air intakes are 3 142 m,3 055 m adits and ramp,air flow is extracted from the No.38,03 and 035 exploration line air shafts.Actual ventilation parameters are measured after the project is completed,showing that the ventilation system is significantly improved,the air volume meets the design criteria,and the underground working conditions are improved.The project creates considerable economic and social benefits for the mine,and at the same time provides valuable experience to the other mines confronting ventilation problems.