According to the cyanide tailings characteristics in a gold mine,hydroperoxide oxidation method,INCO method,cyanide precipitation method are used respectively to carry out detoxification treatment of cyanide tailings.The results show that hydroperoxide method has little effect on the removal of total cyanide,while both INCO method and cyanide precipitation method can produce tailings that meet the requirement of HJ 943—2018 Technical Specification for Pollution Control of Cyanide Leaching Residue in Gold Industry for the pollution control of tailings pond disposal;with comprehensive considerations of reagent cost and process control difficulties,it is recommended that the cyanide precipitation method be used for the detoxification treatment.The research provides reference for industrial application of cyanide detoxification treatment.