As Fankou Lead-Zinc Mine has gradually entered the stage of deep mining,its existing ventilation system is also facing greater pressure.The optimization of deep ventilation system has become the focus of the current ventilation management.A three-dimensional simulation model of deep ventilation system is established by using VentNetLab ventilation simulation software to simulate the deep ventilation system and calculate the ventilation network.There are four main problems in the deep ventilation system of Fankou Lead-Zinc Mine,such as excessive ventilation resistance,serious circulating air,insufficient deep air intake and unreasonable air flow control.In view of the above problems,it is proposed to renovate the deep ventilation system from four aspects:adding air intake measures shaft,optimizing ventilation structure in deep panel,tapping air intake potential in deep panel and adding auxiliary fan,in order to improve the current situation of ventilation system in deep panel and increase the safety production capacity of deep panel of Fankou Lead-Zinc Mine.