The gold and silver grades in certain flotation tailings are higher than 2.5 g/t and 100 g/t respectively,making the tailings worth recovering.The experiment used oxygen pressure pretreatment-cyanidation leaching for recovery,and investigated the effect of oxygen pressure,temperature,reaction time,liquid-solid ratio and additives on gold and silver leaching rates.The results show that when the pretreatment oxygen pressure is 1.5-1.8 MPa,tempera-ture is 180 ℃-200 ℃,reaction time is 1.0 h and liquid-solid ratio is 3∶1,the gold cyanidation leaching rate of flotation tailings after pretreatment is 81.77 % and silver leaching rate is 33.29 %;the addition of additives is beneficial to improving silver leaching rate.The research can provide technical reference for industrial recovery of gold and silver from flotation tailings.