Laser denudation-inductively coupled plasma-mass spectrometry is used for determination of 18 the impurity elements such as Ag,As,Bi,Cd,Co,Cr,Cu,Fe,Ir,Mg,Mn,Ni,Pb,Pd,Pt,Rh,Te,Zn.Standard curve is mapped with gold standard samples and optimal working parameters are optimized.When the laser energy is 60 %,denudation bore diameter is 110 μm,scanning rate is 50 μm/s,impulse rate is 10 Hz and the carrier gas flow is 0.80 L/min,the linear coefficient of the standard curve of each element is 0.965 0-0.999 5,the detection limit of each element is 0.010-0.660 μg/g,the relative standard deviation (RSD) is 0.75 %-11.42 %(except for Fe,Ni).The results of impurity elements determination in pure gold with this method are consistent with ICP-AES.