According to the property of the mixed concentrates obtained from mixed copper-lead flotation of a complex sulfide copper-lead-zinc ore from Yunnan,copper-lead flotation separation experimental test is carried out and investigates major factors that influence reagent removal treatment and flotation separation.The results show that under optimal conditions environment-friendly and efficient copper mineral inhibitor BK520 and lead mineral collector BK902 are used as combined ore-dressing reagent,Pb recovery rate is 93.87 %,Cu recovery is 92.33 %,indicating good ore-dressing index.