As an objective natural phenomenon greatly affected by climate,seasonal temperature and so on,natural air pressure is difficult to control and is one of the uncontrollable factors that affect the mine ventilation system.To overcome the effect of natural air pressure on the ventilation system,the method of calculating natural air pressure is deduced by analyzing the principles and influencing factors of natural air pressure formation.Based on this study,a case study of a mine with adit development influenced by natural air pressure is used to calculate the impact of natural air pressure on the mine by example detection analysis,and related optimized technical measures are made,in order to solve the problem that the mine is affected by natural air pressure and seasonal wind direction change in each main adit.