Abstract: A high pyrrhotite type copper-lead-zinc polymetallic ore in Qinghai contains 35.00 % pyrrhotite and 6.00 % pyrite. Conventional flotation process can not effectively inhibit the flotation of pyrite and pyrrhotite and separate valuable elements. By adopting the magnetic separation-mixed flotation of copper， lead and sulfur-zinc recovery from tailings process， closed circuit test obtains good index： copper grade is 13.15 %， lead grade is 7.59 %， copper recovery rate is 75.10 %， lead recovery rate is 69.49 % in mixed concentrate of copper and lead； zinc grade is 48.05 %， zinc recovery rate is 76.33 % in zinc concentrate； the separation and recovery of each primary element is realized.