Abstract: For a gold ore in Qinghai， based on investigation of the ore type and gold dissemination state， three processes are compared in tests including raw ore leaching by environment-friendly gold leaching agent， flotation-flotation tailings leaching by environment-friendly gold leaching agent， Nelson gravity separation-gravity tailings leaching by environment-friendly gold leaching agent. Finally， the Nelson gravity separation-gravity tailings leaching by environment-friendly gold leaching agent process is recommended. The process can lead to gold recovery rate of 97.04 %， which is easy to operate， environment-friendly and effective， the process are reliable， and can provide basics for mine development and production.