Abstract: In light of serious argillization， fine disseminated gold grain size， largely different gold-bearing mineral hardness and disintegration degree in the run-of-mill gold ores of a large-scale Carlin-type gold mine in Gansu， a number of beneficiation processes are studied. The results show that the gravity separation-stage grinding and flotation-tailings leaching process can obtain good index： the gold grade is 1603.00 g/t in the gravity concentrate and 52.72 g/t in the flotation concentrate. The gold grade in flotation tailings decreases to 0.64 g/t after the tailings are leached by environment-friendly gold leaching reagent， and overall gold recovery rate reaches 82.68 ％.