Abstract: Yantonglazi District is located in north of the Yanbian superimposed basin， the northeastern part of Liangjiang-Mingyue gold polymetallic metallogenic belt with good ore-forming conditions. Gold arsenic mineralization is mainly developed in this area， and the ore bodies mainly occur in the Permian Miaoling Formation and are controlled by NE-trending faults and secondary faults. The results of 1：10000 soil geochemical survey show that As， Au， Ag， Sb and Pb are unevenly distributed and highly dispersed with concentration trend， indicating that they have certain prospecting potential， and 18 Au anomalies and 6 comprehensive anomalies are delineated. Through anomaly verification， it is determined that the HT-6 comprehensive anomaly composed of Au， Ag， Cu， Zn， As， Sb， Pb， W， Mo and Bi elements is ore-induced anomaly， and 3 ore bodies have been discovered. Based on the analysis of the prospecting prospect in Yantonglazi District， it is considered that it has good prospecting prospects， which can be used as a reference for the next-step ore prospecting and exploration in this area and its neighboring areas.