Abstract: On a comprehensive basis of the characteristics of geological， geophysical and geochemical anomalies， the 1：50000 stream sediment survey in Wuergou area was carried out， finding that the ore-bearing strata in Wuergou area are the Kawabulake Rock Group of Jixian System and the Tianger Formation of Upper Devonian； the ore-controlling structure is Bingdaban ductile shear zone； the alteration of surrounding rock is mainly silicification， jarosite， potassification， peacock petrification and serpentine while the mineralization is mainly scheelite and carbonization； the prospecting target area (B-2) of Modetu Au-Cu-graphite and the prospecting target area (A-1) of Guoguang North tungsten-molybdenum are determined， and the geological-geophysical-geochemical comprehensive prospecting model is constructed， providing a new idea and direction for next-step ore prospecting work.