Abstract: In the case study of a silver polymetallic ore， based on a systematic mineralogy study， a small-scale test is carried out to determine optimal process flow and process conditions. The results show that when the process flow of silver lead partial preferential flotation-zinc recovery from tailings is used， grinding fineness of -0.045 mm accounts for 85 %， CG801 dosage is 2000 g/t， CuSO₄ dosage in zinc flotation is 400 g/t， and so on， good indexes are obtained. Silver and lead in silver lead concentrates are 14999.71 g/t and 25.09 % respectively， silver and lead recovery rates are 87.70 % and 91.82 % respectively； silver and zinc grades in zinc concentrates are 1398.98 g/t and 41.97 %， the silver recovery rate is 1.74 %， the zinc recovery rate is 64.12 %； total silver recovery rate is 89.44 %.