Abstract: A copper-zinc polymetallic sulfide ore contains 0.38 % copper， 1.69 % zinc， and 12.48 % sulfur， of which copper， zinc， and sulfur are the main valuable elements for recovery. To achieve effective separation and recovery of copper， zinc， and sulfur， experimental research on the ore-dressing process and reagent regime was carried out. The results showed that using a copper-zinc-sulfur preferential flotation process， that is， separating copper first， then zinc， and finally sulfur， with Z-200 as the copper collector， zinc sulfate and sodium sulfite combination as the zinc depressant， lime as the sulfur depressant， and ethyl xanthate and butyl xanthate as the zinc collector， closed-circuit experiments obtained a copper grade of copper concentrates of 21.95 %， a copper recovery rate of 80.52 %； a zinc grade of zinc concentrates of 45.29 %， a zinc recovery rate of 83.22 %； and a sulfur grade of sulfur concentrates of 49.79 % and a sulfur recovery rate of 85.02 % for experimental indicators.