Abstract: A detailed study was conducted on the process mineralogy of the gold-silver-lead-zinc polymetallic ores in a mine in Henan Province to understand the metallurgical type， main target minerals for recovery， particle size characteristics， and dissemination characteristics， providing data support for the development of a reasonable separation process and technical conditions. Based on the metallurgical characteristics of the ore and target minerals， a separation process was determined as raw ore gravity separation-flotation of gold， silver， and lead from gravity separation tailings-flotation of zinc from gold-silver-lead tailings， resulting in effective recovery of gold， silver， lead， and zinc.