Abstract: In order to further improve the recovery index of refractory microfine-dissemination gold ore in Qinghai Province， a detailed process mineralogy study was conducted. The results showed that the main factors affecting gold recovery were the recovery of fine and micro-fine pyrite and arsenopyrite. Due to the difficulty of monomer dissociation of most fine and micro-fine pyrite and arsenopyrite during the grinding process， some gold minerals were lost. In addition， fine-grained gold inclusion by vein minerals was also an important form of gold mineral loss. It is suggested to use a flotation process with staged grinding and separation to improve gold recovery rate.