Abstract: The ore of a high-sulfur polymetallic gold deposit in Fujian contains a gold grade of 4.45 g/t， silver grade of 60.10 g/t， copper grade of 0.47 %， zinc grade of 2.96 %， and sulfur content of 8.56 %. To improve resource utilization， flotation tests were conducted based on process mineralogy， using HS-1 and HZ-1 as selective inhibitors for pyrite and sphalerite， reducing the lime dosage and achieving copper-zinc-sulfur separation under low alkaline conditions. The test results show that gold is mainly concentrated in high-copper gold concentrate and zinc-bearing gold concentrate， with gold grades of 35.47 g/t， silver grades of 614.17 g/t， and copper grades of 5.69 % in the high-copper gold concentrate. The gold grades are 14.36 g/t and zinc grades are 16.07 % in zinc-bearing concentrates. The total recovery rates of gold， silver， copper， and zinc reached 91.39 %， 83.95 %， 87.11 %， and 76.38 %， respectively， effectively utilizing resources and significantly enhancing the economic efficiency of the enterprise.