Abstract: Two types of sulfide deposits occur on the northern margin of the Quren Basin: one type is pyrite deposits represented by Xigangzhai, Luocun, and Yangjiaoshan; the other is pyrite-Pb−Zn deposits represented by Fankou and Yangliutang. The genetic relationship and differences between these two types have long attracted attention. In this study, the genetic mineralogical characteristics of different generations of pyrite from 3 representative deposits （Luocun, Yangliutang, and Fankou） on the northern margin of the Quren Basin were investigated by means of optical microscopy, scanning electron microscopy, X-ray diffraction, monomineralic chemical composition analysis, electron microprobe analysis （EPMA）, and sulfur isotope analysis. The results show that hydrothermal pyrite in the representative deposits can be divided into 3 generations. In the pyrite deposits, the first-generation pyrite （Py1） and second-generation pyrite （Py2） are characterized by nondevelopment of annular structures, S enrichment, Fe depletion, low As and Co content, and a single sulfur source. As for the pyrite-Pb−Zn deposits, the Py1 exhibits genetic typomorphic characteristics similar to those of Py1 in the pyrite deposits. The Py2 is characterized by developed annular structures, Fe enrichment, S depletion, high As and Co content, and multiple sulfur sources. The third-generation pyrite （Py3） is characterized by fine grains, S enrichment, Fe depletion, high As and Co content, and multiple sulfur sources. These characteristics indicate that the mineralization process of the pyrite deposits is relatively simple, whereas that of the pyrite-Pb−Zn deposits is complex, resulting from superposition and transformation by multiphase and multistage mineralization. It is thus concluded that the Pb−Zn sulfide deposits on the northern margin of the Quren Basin constitute a typical polygenetic composite Pb−Zn sulfide metallogenic system with multiple sources of ore-forming materials, multiple physicochemical conditions of mineralization, and multiple ore-controlling factors. The study of genetic typomorphic characteristics of multi-generation minerals can serve as an effective tool for determining the types of polygenetic composite deposits and elucidating their genetic mechanisms.