Abstract: A large amount of cyanide tailings are produced in the production process of a gold mine, which have safety and environmental risks. The total cyanide compounds contained in the tailings need to be treated to below the detection limit (0.04 mg/kg) of HJ745—2015 "Soil - Determination of cyanide and total cyanide - Spectrophotometric method". The cyanide removal methods such as traditional oxidation method and combined treatment process were discussed. The combined process of cyanide tailings slurry + OOT method + PAM method met the requirements. The optimal treatment parameters were: after pressure filtration of cyanide tailings (pulp concentration about 40 %), the filter cake (moisture content about 20 %) was slurried with a liquid-solid ratio of 5:1, OOT reagent dosage 0.4 g/kg_{dry ore}, PAM dosage 2.0 g/kg, PAM reaction time 2 h. After treatment, the total cyanide compounds in the filter residue reached the target requirement.