Abstract: The zinc concentrate of a zinc beneficiation plant in Fujian contains 47.33% zinc, 1.29% copper, and 0.49% molybdenum, with copper and molybdenum not effectively recovered. For this zinc concentrate, experimental research was conducted using a regrinding and agent removal-copper and molybdenum mixed flotation-copper and molybdenum separation process. The copper and molybdenum mixed flotation process employed a rougher stage, two scavenging stages, and three cleaning stages, followed by regrinding of the rougher concentrate, while the copper and molybdenum separation process included a rougher stage, a scavenging stage, and four cleaning stages. The closed-circuit test of the entire process yielded a copper concentrate containing 20.11% copper and 0.78 g/t gold, with a copper recovery rate of 65.9%; a molybdenum concentrate containing 39.49% molybdenum and 18.28 g/t rhenium, with a molybdenum recovery rate of 93.0%; and a zinc concentrate containing 49.53% zinc, with a recovery rate of 99.0%. This effectively reduced the impurities of copper and molybdenum in the zinc concentrate, while obtaining high-quality copper and molybdenum concentrates, achieving efficient separation of zinc, copper, and molybdenum.