Abstract: An experimental study was conducted on a combined process of semi-autogenous grinding and flash flotation for a gold ore. By performing mineralogical analysis, grindability tests, and conditional experiments involving conventional flotation and flash flotation, the comminution characteristics and flotation behavior of the ore were systematically investigated. The results indicate that the ore is easily breakable and grindable, with a low Bond work index (W_iBM of 16.3 kW·h/t). Additionally, its impact resistance and abrasion resistance parameters (A×b = 70.47, ta = 0.82) suggest it is suitable for the semi-autogenous grinding process. Conventional flotation achieves a gold recovery of 87.30 %. Based on this, the introduction of flash flotation enables the pre-concentration of 30.01 % of the gold in the coarse fraction (with −0.5 mm accounting for 80 %). In the closed-circuit test of the combined process, the comprehensive gold recovery reaches 88.95 %, which is an improvement of 1.65 percentage points compared to conventional flotation alone. The gold grade in the tailings decreases to 0.41 g/t. This combined process achieves the early recovery of coarse gold minerals, effectively alleviating issues of overgrinding and slime formation. It provides a feasible technological pathway for improving the separation efficiency of similar ores while achieving energy conservation and consumption reduction.