Abstract: The Qiushuwan copper polymetallic deposit is one of the typical copper polymetallic deposits in southwestern Henan province. Based on a systematic analysis of metallogenic geological bodies, tectonic systems, wall-rock alteration, ore-forming material sources, and mineralization stages, a "trinity-based" prospecting prediction model was established for the Qiushuwan copper polymetallic deposit. The results show that the Mesozoic tectonic movement has exerted multi-stage influences on the formation of the deposit. During the early stage, a prototype tectonic breccia belt developed. In the later stage, the upwelling of magmatic hydrothermal fluids led to the formation of diapiric structures and secondary fractures at the upwelling center, and the subsequent emplacement of these fluids produced skarn-type and porphyry-type Cu−Mo ore bodies. Within the tectonic breccia belt, a rapid decrease in the temperature and pressure of magmatic hydrothermal fluids resulted in the formation of medium- to high-temperature explosive breccia-type copper ore bodies. Slightly farther from the center of magmatic upwelling, medium- to low-temperature lead−zinc−silver ore bodies form. The prospecting prediction model indicates that the deep exploration targets are concentrated in the southwestern parts of the F₄ and F₁₅ faults at elevations of –200 to 300 m, which constitute the key prospecting target area. In addition, the southern part of the concealed syncline is also a favorable area for mineral exploration.