Abstract: To study the application of stream sediment survey in mineral prospective survey, the Wangxia−Baisha area, where a 1∶50 000 mineral prospective survey has been carried out, was selected for research. Stream sediment survey data for 15 elements were analyzed and compared to compile element dispersion plots and summarize the distribution and enrichment characteristics of each element. Factor analysis was conducted, R-type cluster analysis dendrograms were generated, and 5 types of element associations were identified. After multiple rounds of iterative elimination of stream sediment survey data, the anomaly lower limits of each element were determined, single-element anomalies were delineated, and Au was identified as the primary ore-forming element, followed by Ag, Cu, Pb, Zn, and Mo. Based on the results of factor analysis and cluster analysis, combined anomalies and comprehensive anomalies were delineated. According to the distribution characteristics of stream sediment anomalies, 3 mineral prospective areas were delineated in the Wangxia−Baisha area, and metallogenic prediction and potential analysis were conducted. The results indicate that the Wangxia−Baisha area has favorable conditions for prospecting magmatic hydrothermal polymetallic deposits, especially Carlin-type gold deposits. After exploration of the comprehensive anomalies, one small gold deposit is discovered, demonstrating that the 1∶50 000 stream sediment survey is a simple and efficient method in regional mineral surveys.