Abstract: The amount of lead−zinc flotation tailings is large, and the tailings cannot fully fill the gob, resulting in disposal problems. Therefore, the efficient resource utilization of lead−zinc flotation tailings is of great importance significance. By taking lead−zinc flotation tailings as the research object, a comprehensive utilization path suitable for lead−zinc flotation tailings was explored. The properties of lead−zinc flotation tailings, including hazardous characteristics, classification of general industrial solid waste, and identification of radionuclides, were analyzed, all of which met the requirements for use. Drying sand was made from lead−zinc flotation tailings flotation by fractional concentration, and then cement-based self-leveling mortar and adhesive were prepared according to a certain proportion. The results show that all the indexes of the prepared drying sand meet the standard requirements, and the alkali activity has no potential harm, so it can be used as construction sand. Cement-based self-leveling mortar and adhesive meet the national industry standards of corresponding products, respectively, and the radioactivity meets the requirements of Class A; the content of hazardous substances in the products meets the relevant limit requirements and has significant market potential. The study successfully solves the problem of comprehensive utilization of lead−zinc flotation tailings as cement-based self-leveling mortar and adhesive, provides a practical technical scheme for resource disposal of lead−zinc flotation tailings, and plays a positive role in promoting the development of the comprehensive utilization industry of non-ferrous metal tailings.