Abstract: In response to the problems of low production efficiency, high boulder yield, and high comprehensive costs encountered in the upward horizontal cut-and-fill mining method at Jinshan Gold Mine, this study conducted a series of research on medium-depth hole blasting parameter optimization technology. Firstly, based on the Livingston blasting crater theory, fundamental medium-depth hole blasting parameters suitable for the rock mass conditions at Jinshan Gold Mine were determined through inversion derivation using single-hole, multi-hole, and inclined bench blasting crater tests. Subsequently, by utilizing the LS-DYNA numerical simulation software, fluid-structure interaction blasting models for both double-hole and multiple-row hole arrangements were established. A comparative simulation analysis of rock damage and fragmentation effects under different blasting pattern parameters （burden × spacing） was performed, leading to the identification of a 1.4 m × 1.2 m blasting pattern as the optimal scheme. Finally, the optimized parameters were validated through field industrial trials. The results demonstrate that the optimized blasting scheme significantly reduces the stope boulder yield, improves the fragmentation uniformity of the blasted ore, and effectively enhances production efficiency. This provides an integrated systematic solution of "experimental study, numerical simulation, and industrial validation" for blasting parameter optimization in similar mines.