Abstract: Deep-buried large-section chambers face challenges such as difficulty in controlling the surrounding rock and increasing support costs. To ensure the stable operation of the chamber group of the 941 m mixing plant in Jinchuan No. 2 Mine, the layout optimization and stability analysis of the large-section chamber group in deep mines were carried out by numerical simulation. Rational section shapes and layout patterns were determined through optimization. Based on the engineering geological conditions of the chamber group of the mixing plant, it is found that the optimal section shape of the large-section chamber under this working condition is the straight wall arc arch section. When arranging the chamber, the main chamber should be preferentially arranged, and the angle between the axis of the chamber and the maximum principal stress should be kept at 45°–60°; the chamber should be vertically arranged as far as possible. The excavation model of the chamber group of the 941 m mixing plant was established, and the displacement change characteristics, stress distribution, and plastic zone expansion characteristics of the whole surrounding rock group were analyzed by numerical simulation; the key parts of the surrounding rock control were identified as the intersections of roadways and chambers, as well as the sidewalls of the three large-section chambers. The research provides some technical guidance and reference for the realization of stability control of surrounding rock in chambers of deep mining, which has both theoretical and practical significance.