Abstract: With more demanding national environmental protection standards,the use of low-toxic and non-toxic environment-friendly gold leaching reagent to replace sodium cyanide in gold mines whose production pressure has been increasing is inevitable.Through column leaching test,the leaching effect of various new environment-friendly gold leaching reagent on leaching of the gold ore in Changshanhao Gold Mine was examined.The results show that CG505 generally is better than No.1 and No.2 gold leaching reagent,and its leaching index is the closest to that of sodium cyanide.Besides,it is environment-friendly,can mitigate the pressure of mine production and is suitable for the application in Changshanhao Gold Mine.