Abstract: In light of serious argillization,fine disseminated gold grain size,largely different gold-bearing mineral hardness and disintegration degree in the run-of-mill gold ores of a large-scale Carlin-type gold mine in Gansu,a number of beneficiation processes are studied.The results show that the gravity separation-stage grinding and flotation-tailings leaching process can obtain good index:the gold grade is 1 603.00 g/t in the gravity concentrate and 52.72 g/t in the flotation concentrate.The gold grade in flotation tailings decreases to 0.64 g/t after the tailings are leached by environment-friendly gold leaching reagent,and overall gold recovery rate reaches 82.68 %.