Abstract: A copper-lead-zinc polymetallic sulfide ore in Qinghai belongs to a complex and refractory  polymetallic sulfide ore,and the relationship between the various minerals and the gangue minerals is extremely complex.In order to make better comprehensive use of the mineral resources,the research on its process mineralogy is carried out,which provided insights into the mineral types,distribution status and process characteristics of copper,lead and  zinc  in the ore.The results show that the copper,lead and zinc minerals in the ore are mainly chalcopyrite,galena and blende,and each of the valuable metal minerals coexists in a close way;the target minerals are finely embedded and distributed unevenly;when grinding fineness -0.074 mm accounts for 75 %,the target minerals are in low disintegration degree.The research results of process mineralogy provide important basic data for the selection of ore-dressing processes.