Abstract: A lead-zinc mine was originally mined using the sublevel drilling and staged open stoping method,which causes large ore loss and leaves potentially risky goafs.For the inclined medium-thick ore body in the mine,the optimization of the filling mining method was carried out.According to the actual technical and economic conditions of mining,sublevel drilling-staged open stope-subsequent filling mining method is recommended to extract the inclined medium-thick ore body in the mine.The designed stope production capacity of the mining method is 450 t/d,the ore loss rate is 22 %,the dilution rate is 13 %,the direct mining cost is 39.18 yuan/t,and the filling cost is 12.65 yuan/t.The research results have certain reference significance for the selection of mining methods for the same type of ore bodies.