Abstract: A detailed study was conducted on the process mineralogy of the gold-silver-lead-zinc polymetallic ores in a mine in Henan Province to understand the metallurgical type,main target minerals for recovery,particle size characteristics,and dissemination characteristics,providing data support for the development of a reasonable separation process and technical conditions.Based on the metallurgical characteristics of the ore and target minerals,a separation process was determined as raw ore gravity separation-flotation of gold,silver,and lead from gravity separation tailings-flotation of zinc from gold-silver-lead tailings,resulting in effective recovery of gold,silver,lead,and zinc.