Abstract: To address the problem of severe ore argillization in the Tanjianshan Gold Mine in Qinghai,laboratory optimization experiments and production practices were conducted on the all-sliming cyanidation ＋ flotation joint process.The results showed that by using asynchronous flotation,the easily floatable gold minerals,gold-bearing minerals,and difficult-to-inhibit clayey products were preferentially enriched in the final concentrate.By reducing the pulp concentration,the influence of clayey minerals conglomeration on gold-bearing minerals encapsulation was mitigated.Additionally,increasing the dosage and adding points of the collector enhanced the capturing ability for refractory gold minerals and gold-bearing minerals.With these 3 measures,the overall gold recovery rate in flotation increased by 15.40 percentage points,and the gold grade in the concentrate improved from 7.10 g/t to 12.29 g/t,while ensuring the normal cyanide removal effect of tailings.The on-site flotation production indicators remained stable,with an increase in monthly economic benefits of approximately 1.71 million yuan.This process improvement can guide similar mines.