Abstract: To ensure the best economic operation during the whole life cycle of mine ventilation systems in Jiama Copper Mine,the ventilation system was simulated by Ventsim mine ventilation 3D simulation software.And by selecting the structure size of key shafts and lanes in the ventilation network from economic perspectives,it was found that the ventilation systems of super large-scale mines had great economic optimization potentials.The study can be used as a reference for similar mines.